YC 1

Product Description

YC 1 is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC₅₀ = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC₅₀ = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G₁ cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Solubility

Preparing Stock Solutions for YC 1

The following data is based on the product molecular weight 304.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.43 mL	32.86 mL
5 mM	0.66 mL	3.29 mL	6.57 mL
10 mM	0.33 mL	1.64 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Teixeira Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4 J.Pharmacol.Exp.Ther. 2006 PMID: 16352702
• Martin YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc.Natl.Sci.U.S.A. 2001 PMID: 11687640
• Wang YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J.Pharmacol.Exp.Ther. 2005 PMID: 15525795
• Ko YC-1, a novel activator of platelet guanylate cyclase. Blood. 1994 PMID: 7527671