XL 413 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5493

Potent and selective Cdc7 inhibitor
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Key Product Details

Description

Potent and selective Cdc7 inhibitor

Alternative Names

BMS 863233

View all Other Kinase Inhibitors »

Product Description

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Product Specifications

Molecular Weight

326.18

Formula

C14H12ClN3O2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

CAS Number

1169562-71-3

PubChem ID

67185304

InChI Key

UNDKJUKLBNARIZ-FVGYRXGTSA-N

SMILES

ClC1=CC=C2C(C(N=[C@@]([C@H]4NCCC4)NC3=O)=C3O2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.52 20

Preparing Stock Solutions for XL 413 hydrochloride

The following data is based on the product molecular weight 326.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.33 mL 76.64 mL 153.29 mL
1 mM 3.07 mL 15.33 mL 30.66 mL
2 mM 1.53 mL 7.66 mL 15.33 mL
10 mM 0.31 mL 1.53 mL 3.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for XL 413 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XL 413 hydrochloride

For research use only

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