Medetomidine hydrochloride

Name: Medetomidine hydrochloride
Brand: Tocris Bioscience
SKU: 5160

Tocris Bioscience, part of Bio-Techne | Catalog # 5160

Citations (7)

COA / SDS

Potent and highly selective α2 agonist

Key Product Details

Description:	Potent and highly selective α₂ agonist
Chemical Name:	4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	236.74

View Full Technical Details for Medetomidine hydrochloride

Technical Data
Citations

Biological Activity for Medetomidine hydrochloride

Medetomidine hydrochloride is a potent, highly selective α₂-adrenoceptor agonist (K_i values are 1.08 and 1750 nM for α₂- and α₁-adrenoceptors respectively). Displays greater selectivity over α₁-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD₂ = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Active Isomer also available.

Compound Libraries for Medetomidine hydrochloride

Medetomidine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Medetomidine hydrochloride

M. Wt	236.74
Formula	C₁₃H₁₆N₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	86347-15-1
PubChem ID	68601
InChi Key	VPNGEIHDPSLNMU-UHFFFAOYSA-N
Smiles	CC(C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Medetomidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.67	100
	DMSO	23.67	100

Preparing Stock Solutions for Medetomidine hydrochloride

The following data is based on the product molecular weight 236.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for Medetomidine hydrochloride

References are publications that support the biological activity of the product.

Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154
Scheinin Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
Savola Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 1986 PMID: 2880852