Dexmedetomidine hydrochloride

Name: Dexmedetomidine hydrochloride
Brand: Tocris Bioscience
SKU: 2749

Tocris Bioscience, part of Bio-Techne | Catalog # 2749

Citations (44)

COA / SDS

Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)

Key Product Details

Description:	Potent, highly selective α₂ agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternative Names:	d-Medetomidine hydrochloride
Chemical Name:	4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity:	≥98%
Molecular Weight:	236.74

View Full Technical Details for Dexmedetomidine hydrochloride

Technical Data
Citations

Biological Activity for Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α₂-adrenoceptor agonist (K_i values are 1.08 and 1750 nM for α₂- and α₁-adrenoceptors respectively). Displays greater selectivity over α₁-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Compound Libraries for Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Dexmedetomidine hydrochloride

M. Wt	236.74
Formula	C₁₃H₁₆N₂.HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	145108-58-3
PubChem ID	6918081
InChi Key	VPNGEIHDPSLNMU-MERQFXBCSA-N
Smiles	C[C@H](C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dexmedetomidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.67	100
	DMSO	23.67	100

Preparing Stock Solutions for Dexmedetomidine hydrochloride

The following data is based on the product molecular weight 236.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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Reconstitution Calculator

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References for Dexmedetomidine hydrochloride

References are publications that support the biological activity of the product.

Fisher Antinociceptive properties of intrathecal dexmedetom. in rats. Eur.J.Pharmacol. 1991 PMID: 1674472
Scheinin Medetomidine - a novel α₂-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α₂-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154