Dexmedetomidine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2749
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Key Product Details
Description
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternative Names
d-Medetomidine hydrochloride
Product Description
Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.Racemate also available.
Product Specifications
Molecular Weight
236.74
Formula
C13H16N2.HCl
Storage
Desiccate at RT
Purity
≥98%
Chemical Name
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
CAS Number
145108-58-3
PubChem ID
6918081
InChI Key
VPNGEIHDPSLNMU-MERQFXBCSA-N
SMILES
C[C@H](C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.67 | 100 | |
| DMSO | 23.67 | 100 |
Preparing Stock Solutions
for Dexmedetomidine hydrochloride
The following data is based on the product molecular weight 236.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.12 mL | 42.24 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.45 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fisher Antinociceptive properties of intrathecal dexmedetom. in rats. Eur.J.Pharmacol. 1991 PMID: 1674472
- Scheinin Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
- Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154
Product Specific Notices for Dexmedetomidine hydrochloride
For research use only
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