Clonidine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0690
α2 agonist. Also I1 ligand
Key Product Details
Description
α2 agonist. Also I1 ligand
Product Description
Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.Product Specifications
Molecular Weight
266.56
Formula
C9H9Cl2N3.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
CAS Number
4205-91-8
PubChem ID
20179
InChI Key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
SMILES
Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.66 | 100 | |
| DMSO | 13.33 | 50 |
Preparing Stock Solutions
for Clonidine hydrochloride
The following data is based on the product molecular weight 266.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.52 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.50 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949
- Silva Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 1996 PMID: 8627569
- Ernsberger clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 1987 PMID: 3030779
- Greney Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 1994 PMID: 7883019
- Armitsu Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 1998 PMID: 9694921
Product Specific Notices for Clonidine hydrochloride
For research use only
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