Wnt-6: Proteins and Enzymes

Wnt-6 is a 46 kDa, secreted, glycoprotein of the Wnt family. Wnt-6 is produced by mammary fibroblasts and ductal epithelium, intestinal crypt cells and limb bud ectoderm. Wnt-6 has been implicated in the process of limb myogenesis. Human Wnt-6 is synthesized as a 365 amino acid (aa) precursor that contains a 341 aa mature region. The mature Wnt-6 molecule contains 24 cysteines and one potential N-linked glycosylation site.

The Wnts make up a large family of secreted proteins with roles in ...