USP14: Proteins and Enzymes

Ubiquitin Specific Peptidase 14 (USP14) is a cytoplasmic protein that belongs to the peptidase C19 family of deubiquitinating enzymes. It has a predicted molecular weight of 56.1 kDa. Human USP14 is 494 amino acids (aa) in length, contains an N-terminal Ubiquitin-like (Ubl) domain (4-80 aa), and shares 97% aa sequence identity with the mouse and rat orthologs. USP14 is one of three deubiquitinating enzymes associated with the 26S Proteasome. It reversibly binds the 19S regulatory particle via ...