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Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor-binding domain.

The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

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114 results for "Spike RBD Proteins and Enzymes" in Products

Spike RBD: Proteins and Enzymes

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor-binding domain.

The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

Products:

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114 results for "Spike RBD Proteins and Enzymes" in Products

BA

His-tag

HEK293 Expressed, High ACE-2 Binding

HEK293 Expressed, High ACE-2 Binding

BA

Biotinylated via Amines

BA

Delta Variant (India) L452R T478K

BA

His-tag

BA

A.23.1 Variant

BA

Val367Phe Point Mutation

BA

Kappa Variant L452R E484Q

Tn5 Insect Cell Expressed, High ACE-2 Binding Analyzed by SEC-MALS

N501Y Mutation found in Alpha, Beta, and Gamma Variants

BA

Mammalian CHO Cell Expressed, High ACE-2 Binding

Beta Variant (South Africa), K417N, E484K, N501Y

HEK293 Expressed

BA
BA
BA

HEK293 Expressed. Trimerization domain.

BA
BA
BA
BA
BA, BA

Biotinylated

Sf21 Expressed, High ACE-2 Binding

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