Sortilin: Proteins and Enzymes

Sortilin is a type I transmembrane glycoprotein that is one of five known members of the mammalian vacuolar protein sorting 10p domain (Vps10p-D) family of sorting receptors. During murine development, sortilin is mainly expressed in the nervous system where it is a receptor for neuropeptides including neurotensin, NGF, and BDNF. Pro-NGF (or the NGF propeptide alone) binds Sortilin with much higher affinity than does mature NGF. Pro-NGF binding to the receptor complex of Sortilin and the NGF Receptor/p75NTR may result in the induction of apoptosis.