Sonic Hedgehog/Shh Products
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
274 results for "Sonic Hedgehog/Shh" in Products
274 results for "Sonic Hedgehog/Shh" in Products
Sonic Hedgehog/Shh Products
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | Q15465 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Sensitivity: | 3.92 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma) |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | Q15465 |
| Applications: | BA |
| Sensitivity: | 2.37 pg/mL |
| Applications: | ELISA |
| Assay Range: | 7.81 - 500 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma) |
| Source: | E. coli |
| Accession #: | Q62226.2 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #5H4 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: Sonic Hedgehog/Shh Antibody (5H4) [NBP2-22126]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Shh-Antibody-5H4-Western-Blot-NBP2-22126-img0004.jpg "Western Blot: Sonic Hedgehog/Shh Antibody (5H4) [NBP2-22126]")
| Source: | E. coli |
| Accession #: | Q15465.1 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Sonic Hedgehog/Shh AntibodyBSA Free [NBP2-22139]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Antibody-Western-Blot-NBP2-22139-img0002.jpg "Western Blot: Sonic Hedgehog/Shh AntibodyBSA Free [NBP2-22139]")
| Source: | E. coli |
| Accession #: | Q62226.2 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #55626 |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #171028 |
| Reactivity: | Human, Mouse, Chicken |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: Sonic Hedgehog/Shh Antibody [NBP1-69270]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Shh-Antibody-Western-Blot-NBP1-69270-img0005.jpg "Western Blot: Sonic Hedgehog/Shh Antibody [NBP1-69270]")
| Assay Range: | 7.81 - 500 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |