SHC1: Lysates

SH2 domain-containing transforming protein C1 (SHC1), also known as SHCA, is a cytoplasmic adaptor protein that is important in the signal transduction from growth factor, cytokine, and lymphocyte antigen receptors. SHC1 contains a PTB/PID domain (aa 156-339), a collagen homology domain (aa 340-487), and an SH2 domain (aa 488-579). Alternate splicing generates additional isoforms that differ in the extent of N-terminal truncation. Activation of Shc1 by phosphorylation at Ser239, Ser240, and ...