S1P5/EDG-8: Small Molecules and Peptides
EDG molecules are G protein-coupled receptors that bind plasma lysophospholipids. The EDG family consists of two subfamilies; the S1P (sphingosine-1-phosphate) subfamily consisting of EDG-1, 3, 5, 6, and 8, and the LPA (lysophosphatidic acid) subfamily that contains EDG-2, 4 and 7. Each receptor is the product of a distinct gene. The S1P family regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, and differentiation.
4 results for "S1P5/EDG-8 Small Molecules and Peptides" in Products
4 results for "S1P5/EDG-8 Small Molecules and Peptides" in Products
S1P5/EDG-8: Small Molecules and Peptides
EDG molecules are G protein-coupled receptors that bind plasma lysophospholipids. The EDG family consists of two subfamilies; the S1P (sphingosine-1-phosphate) subfamily consisting of EDG-1, 3, 5, 6, and 8, and the LPA (lysophosphatidic acid) subfamily that contains EDG-2, 4 and 7. Each receptor is the product of a distinct gene. The S1P family regulates essential cellular processes such as proliferation, migration, cytoskeletal organization, and differentiation.
Endogenous agonist at S1P1-5
| Chemical Name: | (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol |
| Purity: | ≥98% (HPLC) |
Potent and selective S1P5 agonist
| Chemical Name: | 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent S1P receptor agonist; also immunosuppressant
| Alternate Names: | Fingolimod,Gilenya |
| Chemical Name: | 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride |
| Purity: | ≥98% (HPLC) |
S1P1 and S1P3 antagonist
| Chemical Name: | 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide |
| Purity: | ≥95% (HPLC) |
