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47 results for "PSENEN" in Products

PSENEN Products

Gamma-secretase subunit PSENEN, also called PEN2 (Presenilin enhancer protein 2) is a 10 kDa member of the PEN2 family. Human PSENEN is 101 amino acids (aa) in length, and is a multipass transmembrane protein. Human PSENEN shares 96% aa sequence identity with mouse and rat PSENEN. Functionally, PSENEN is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.

Recombinant Monoclonal Antibody

Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Monoclonal Clone #JE41-28
Applications: IHC, WB, ICC/IF, Flow
Western Blot: PSENEN/PEN2 Antibody (JE41-28) [NBP2-75632]
(9)
Reactivity: Human, Mouse, Rat, Canine, Bovine, +2 More
Details: Rabbit IgG Polyclonal
Applications: WB
Western Blot: PSENEN/PEN2 Antibody [NBP2-24611]
Reactivity: Human, Mouse
Details: Rabbit IgG Polyclonal
Applications: WB, IP
Western Blot: PSENEN/PEN2 Antibody [NB300-227]

Recombinant Monoclonal Antibody

Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Monoclonal Clone #6J5O4
Applications: WB, ICC/IF
Western Blot: PSENEN/PEN2 Antibody (6J5O4) [NBP3-16676]
(3)
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: IHC
Immunohistochemistry-Paraffin: PSENEN/PEN2 Antibody [NBP2-47319]
Applications: WB, ELISA, MA, AP
Applications: AC
Applications: WB
Western Blot: PSENEN/PEN2 Overexpression Lysate [NBL1-14862]

γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Chemical Name: (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
Purity: ≥99% (HPLC)
Using DAPT to differentiate hiPSCs into dopaminergic neurons
(2)

DAPT synthesized to Ancillary Material Grade

Chemical Name: (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester
Purity: ≥99%
DAPT synthesized to Ancillary Material Grade

γ-secretase inhibitor; inhibits Notch pathway

Alternate Names: Dibenzazepine,YO-01027
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98% (HPLC)
γ-secretase inhibitor; inhibits Notch pathway

Highly potent γ-secretase inhibitor; orally bioavailable

Alternate Names: BMS-708163
Chemical Name: (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Purity: ≥98% (HPLC)
Highly potent γ-secretase inhibitor; orally bioavailable

γ-secretase pseudo-inhibitor

Chemical Name: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide
Purity: ≥98% (HPLC)
γ-secretase pseudo-inhibitor
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