Prostaglandin E2/PGE2: Small Molecules and Peptides

Prostaglandin E2 (PGE2) is a prostanoid fatty acid derivative of arachidonic acid whose synthesis can be blocked by corticosteroids or by nonsteroidal anti-inflammatory drugs (NSAIDs). It is produced by a wide variety of tissues and is elevated in many bodily fluids during inflammation. PGE2 interacts with EP1, 2, 3, and 4 receptors to induce a complex range of effects. In the kidney, this includes stimulation of renin release and both promotion and inhibition of salt and water absorption. PGE2 ...