Skip to main content

126 results for "Presenilin-2" in Products

Presenilin-2 Products

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

DAPT synthesized to Ancillary Material Grade

Chemical Name: (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester
Purity: ≥99%
DAPT synthesized to Ancillary Material Grade
R&D Systems VersaClone cDNA Plasmids

γ-secretase inhibitor; inhibits Notch pathway

Alternate Names: Dibenzazepine,YO-01027
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98% (HPLC)
γ-secretase inhibitor; inhibits Notch pathway

Highly potent γ-secretase inhibitor; orally bioavailable

Alternate Names: BMS-708163
Chemical Name: (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Purity: ≥98% (HPLC)
Highly potent γ-secretase inhibitor; orally bioavailable

Potent γ-secretase inhibitor

Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98% (HPLC)
Potent γ-secretase inhibitor

γ-secretase inhibitor; attenuates amyloid plaque deposition

Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
Purity: ≥98% (HPLC)
γ-secretase inhibitor; attenuates amyloid plaque deposition

Potent γ-secretase inhibitor

Chemical Name: 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid
Purity: ≥98% (HPLC)
Potent γ-secretase inhibitor
Reactivity: Human
Details: Mouse IgG1 Monoclonal Clone #149903
Reactivity: Human
Details: Mouse IgG1 Monoclonal Clone #149903
Reactivity: Human
Details: Goat IgG Polyclonal

γ-secretase pseudo-inhibitor

Chemical Name: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide
Purity: ≥98% (HPLC)
γ-secretase pseudo-inhibitor
Reactivity: Human
Details: Mouse IgG1 Monoclonal Clone #149903
Reactivity: Human
Details: Goat IgG Polyclonal
Applications: ELISA
Reactivity: Human
Details: Goat IgG Polyclonal
Reactivity: Human
Details: Goat IgG Polyclonal
Reactivity: Human
Details: Goat IgG Polyclonal
Results Per Page
5 10 25 25 50
/ 6