Human Presenilin-2 N-Terminal Fragment Alexa Fluor™ Plus 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF153AFP488
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Label
Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Specificity
Detects human Presenilin‑2 N-Terminal Fragment in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Presenilin‑1 N-Terminal Fragment (aa 1‑80) and recombinant human Presenilin‑2 C-Terminal Fragment (aa 308‑388) is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications
Application
Recommended Usage
Immunohistochemistry
Optimal dilution of this antibody should be experimentally determined.
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: Presenilin-2
Presenilin‑2 (PS-2 and PSEN2) is a catalytic subunit of the gamma-secretase complex. Presenilin‑2 may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Heterogeneous proteolytic processing of Presenilin‑2 generates N-terminal (aa 1-297) and C-terminal (aa 298-248) fragments. Presenilin 1 and Presenilin 2 determine gamma-secretase activity, which is responsible for cleaving the amyloid precursor protein (APP). In turn, APP cleavage can produce amyloid-beta, which is the primary component of plaques in the brains of Alzheimer’s disease patients. Full length, approximately 50 kDa, and the approximately 30 kDa N-terminal fragment of Presenilin-2 were identified by western blotting in extracted rodent pancreas but only the 30 kDa fragment was detected in mouse islets and human insulinoma. Within a sequence correspondent to the immunogen, human PS-2 shares 87% aa sequence identity with mouse and rat PS-2.
Additional Presenilin-2 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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