250 results for "Presenilin-1" in Products
Presenilin-1 Products
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
![Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-APS-18-Western-Blot-NB100-74510-img0013.jpg "Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510]")
DAPT synthesized to Ancillary Material Grade
![Western Blot: Presenilin-1 Antibody (APS 11) [NB300-749]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-APS-11-Western-Blot-NB300-749-img0007.jpg "Western Blot: Presenilin-1 Antibody (APS 11) [NB300-749]")
γ-secretase inhibitor; inhibits Notch pathway
![Western Blot: Presenilin-1 AntibodyBSA Free [NBP1-76792]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-Western-Blot-NBP1-76792-img0002.jpg "Western Blot: Presenilin-1 AntibodyBSA Free [NBP1-76792]")
![Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NBP1-33611]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-Immunohistochemistry-Paraffin-NBP1-33611-img0011.jpg "Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NBP1-33611]")
![Presenilin-1 [p Ser310] Antibody (24GB4510)](https://resources.rndsystems.com/images/products/nbp3-51649_-immunocytochemistry-immunofluorescence-639228360389597241.png "Immunocytochemistry/ Immunofluorescence: Presenilin-1 [p Ser310] Antibody (24GB4510)[NBP3-51649] -")
Potent γ-secretase inhibitor
γ-secretase inhibitor; attenuates amyloid plaque deposition
Potent γ-secretase inhibitor
Highly potent γ-secretase inhibitor; orally bioavailable
γ-secretase pseudo-inhibitor
![Western Blot: Presenilin-1 AntibodyBSA Free [NB200-130]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-Western-Blot-NB200-130-img0001.jpg "Western Blot: Presenilin-1 AntibodyBSA Free [NB200-130]")
![Immunocytochemistry/ Immunofluorescence: Presenilin-1 Antibody [NBP2-57002]](https://resources.rndsystems.com/images/products/Presenilin-1-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-57002-img0001.jpg "Immunocytochemistry/ Immunofluorescence: Presenilin-1 Antibody [NBP2-57002]")