PERK Products
PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism. Phosphorylation of eIF2 alpha by PERK also selectively promotes the expression of UPR target genes such as Chop and BiP. PERK may also play a role in tumor cell adaptation to hypoxic stress by regulating the translation of angiogenic factors necessary the development of functional microvessels. Mutations in PERK are responsible for the rare autosomal-recessive disorder, Wolcott-Rallison syndrome (WRS).
46 results for "PERK" in Products
46 results for "PERK" in Products
PERK Products
PERK, a type 1 endoplasmic reticulum (ER) membrane kinase, mediates eIF2 alpha phosphorylation at Ser51 during the UPR (unfolded protein response). Protein synthesis is inhibited, thereby reducing the burden of protein substrate for the ER folding and degradation mechanism. Phosphorylation of eIF2 alpha by PERK also selectively promotes the expression of UPR target genes such as Chop and BiP. PERK may also play a role in tumor cell adaptation to hypoxic stress by regulating the translation of angiogenic factors necessary the development of functional microvessels. Mutations in PERK are responsible for the rare autosomal-recessive disorder, Wolcott-Rallison syndrome (WRS).
| Chemical Name: | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Chicken, Avian - Chicken |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunohistochemistry-Paraffin: PERK Antibody [NBP1-80930]](https://resources.bio-techne.com/images/products/PERK-Antibody-Immunohistochemistry-Paraffin-NBP1-80930-img0010.jpg "Immunohistochemistry-Paraffin: PERK Antibody [NBP1-80930]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Mouse |
| Details: | Rabbit Serum Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, IP, +1 More |
![Western Blot: PERK Antibody [NBP1-78017]](https://resources.bio-techne.com/images/products/PERK "Western Blot: PERK Antibody [NBP1-78017]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
![Western Blot: PERK Overexpression Lysate [NBL1-10177]](https://resources.bio-techne.com/images/products/PERK-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10177-img0002.jpg "Western Blot: PERK Overexpression Lysate [NBL1-10177]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #0A1E6 |
| Applications: | IHC, ELISA |
![PERK [p Thr982] Antibody (0A1E6)](https://resources.bio-techne.com/images/products/nbp3-33575_rabbit-perk-p-thr982-mab-0a1e6-101220241243981.jpg "Immunohistochemistry: PERK [p Thr982] Antibody (0A1E6) [NBP3-33575] -")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: PERK Antibody [NBP3-12891]](https://resources.bio-techne.com/images/products/PERK-Antibody-Western-Blot-NBP3-12891-img0001.jpg "Western Blot: PERK Antibody [NBP3-12891]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Chicken Polyclonal |
| Applications: | IHC, WB, ELISA, IP, DB |
![Western Blot: PERK Antibody [NBP3-12193]](https://resources.bio-techne.com/images/products/PERK-Antibody-Western-Blot-NBP3-12193-img0001.jpg "Western Blot: PERK Antibody [NBP3-12193]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit Polyclonal |
| Applications: | IHC, WB, ELISA, IP, DB |
![Immunohistochemistry-Paraffin: PERK Antibody [NBP3-12194]](https://resources.bio-techne.com/images/products/PERK-Antibody-Immunohistochemistry-Paraffin-NBP3-12194-img0001.jpg "Immunohistochemistry-Paraffin: PERK Antibody [NBP3-12194]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #5G5 |
| Applications: | WB, ELISA |
![Western Blot: PERK Antibody (5G5)BSA Free [NBP1-51661]](https://resources.bio-techne.com/images/products/PERK-Antibody-5G5-Western-Blot-NBP1-51661-img0001.jpg "Western Blot: PERK Antibody (5G5)BSA Free [NBP1-51661]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #7B10 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
![PERK Antibody [CoraFluor™ 1]](https://resources.bio-techne.com/images/products/af3999cl1_goat-perk-pab-corafluor-1-129202514561715.png "Product Feature: CoraFluor Probes for TR-FRET")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |