PD-L2/B7-DC Products
PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
394 results for "PD-L2/B7-DC" in Products
394 results for "PD-L2/B7-DC" in Products
PD-L2/B7-DC Products
PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #176611 |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Source: | NS0 |
| Accession #: | Q9BQ51.2 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: PD-L2/B7-DC/PDCD1LG2 AntibodyBSA Free [NBP1-76770]](https://resources.bio-techne.com/images/products/PD-L2-B7-DC-PDCD1LG2-Antibody-Western-Blot-NBP1-76770-img0020.jpg "Western Blot: PD-L2/B7-DC/PDCD1LG2 AntibodyBSA Free [NBP1-76770]")
| Assay Range: | 93.8 - 6,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #176605 |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Source: | HEK293 |
| Accession #: | Q9BQ51.2 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q9WUL5 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #168633 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI7B10 |
| Applications: | IHC, WB, Flow |
![Western Blot: PD-L2/B7-DC/PDCD1LG2 Antibody (OTI7B10) [NBP2-46347]](https://resources.bio-techne.com/images/products/PD-L2-B7-DC-PDCD1LG2-Antibody-OTI7B10-Western-Blot-NBP2-46347-img0009.jpg "Western Blot: PD-L2/B7-DC/PDCD1LG2 Antibody (OTI7B10) [NBP2-46347]")