7 results for "NPY Receptor Antagonists Small Molecules and Peptides" in Products
NPY Receptor Antagonists: Small Molecules and Peptides
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.
All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.
Highly selective and potent non-peptide NPY Y5 receptor antagonist
| Chemical Name: | N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo
| Alternate Names: | BIIE 0246 2HCl,BIIE0246 2HCl |
| Chemical Name: | N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Highly selective NPY Y1 receptor antagonist
| Chemical Name: | N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate |
| Purity: | ≥98% (HPLC) |
Potent NPY Y2 receptor antagonist
| Chemical Name: | N-[4-[(Dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide |
| Purity: | ≥98% (HPLC) |
NPY Y2 receptor antagonist
| Chemical Name: | N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide |
| Purity: | ≥98% (HPLC) |
Potent, selective non-peptide NPY Y5 receptor antagonist
| Chemical Name: | 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione |
| Purity: | ≥98% (HPLC) |
Potent NPY Y5 receptor antagonist
| Chemical Name: | N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide |
| Purity: | ≥98% (HPLC) |
