L-152,804

Tocris Bioscience, part of Bio-Techne | Catalog # 1382

Potent, selective non-peptide NPY Y5 receptor antagonist
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Key Product Details

Description

Potent, selective non-peptide NPY Y5 receptor antagonist

View all NPY Receptor Antagonists »

Product Description

L-152,804 is a potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.

Product Specifications

Molecular Weight

366.46

Formula

C23H26O4

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione

CAS Number

6508-43-6

PubChem ID

3765615

InChI Key

XQDXIHYKAGHZRX-UHFFFAOYSA-N

SMILES

CC1(C)CC(=O)C(C2C3=C(OC4=C2C(=O)CC(C)(C)C4)C=CC=C3)C(=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.65 100

Preparing Stock Solutions for L-152,804

The following data is based on the product molecular weight 366.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.64 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for L-152,804

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-152,804

For research use only

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