SF 11

Name: SF 11
Brand: Tocris Bioscience
SKU: 3898

Tocris Bioscience, part of Bio-Techne | Catalog # 3898

Citations (4)

COA / SDS

NPY Y2 receptor antagonist

Key Product Details

Description:	NPY Y₂ receptor antagonist
Chemical Name:	N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity:	≥98% (HPLC)
Molecular Weight:	446.6

View Full Technical Details for SF 11

Technical Data
Citations

Biological Activity for SF 11

SF 11 is an NPY Y₂ antagonist (IC₅₀ = 199 nM). Displays no affinity for Y₁ receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

Compound Libraries for SF 11

SF 11 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SF 11

M. Wt	446.6
Formula	C₂₇H₃₀N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	443292-81-7
PubChem ID	2936384
InChi Key	PMEQBGAGFZDWQX-UHFFFAOYSA-N
Smiles	S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SF 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.66	100
	ethanol	22.33	50

Preparing Stock Solutions for SF 11

The following data is based on the product molecular weight 446.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.39 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for SF 11

References are publications that support the biological activity of the product.

Domin Characterization of the brain penetrant neuropeptide Y Y₂ receptor antagonist SF-11. ACS Chem.Neurosci. 2019 PMID: 31267743
Brothers Selective and brain penetrant neuropeptide Y Y₂ receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 2010 PMID: 19837904