NADPH Oxidase Inhibitors: Small Molecules and Peptides

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS). NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of responses, including cell growth and apoptosis, angiogenesis, innate ...