Apocynin

Name: Apocynin
Brand: Tocris Bioscience
SKU: 4663
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4663

(1)

Citations (52)

COA / SDS

NADPH-oxidase inhibitor

Key Product Details

Description:	NADPH-oxidase inhibitor
Chemical Name:	4'-Hydroxy-3'-methoxyacetophenone
Purity:	≥98% (HPLC)
Molecular Weight:	166.17

View Full Technical Details for Apocynin

Technical Data
Citations / Reviews (1)

Biological Activity for Apocynin

Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.

Compound Libraries for Apocynin

Apocynin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Apocynin

M. Wt	166.17
Formula	C₉H₁₀O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	498-02-2
PubChem ID	2214
InChi Key	DFYRUELUNQRZTB-UHFFFAOYSA-N
Smiles	CC(C1=CC(OC)=C(O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Apocynin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.62	100
	ethanol	16.62	100

Preparing Stock Solutions for Apocynin

The following data is based on the product molecular weight 166.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.02 mL	30.09 mL	60.18 mL
5 mM	1.20 mL	6.02 mL	12.04 mL
10 mM	0.60 mL	3.01 mL	6.02 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

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Reconstitution Calculator

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References for Apocynin

References are publications that support the biological activity of the product.

Impellizzeri Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 2011 PMID: 21147071
Heumüller Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008 PMID: 18086956
Stolk Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 1994 PMID: 8018341