Apocynin
Tocris Bioscience, part of Bio-Techne | Catalog # 4663
NADPH-oxidase inhibitor
Product Description
Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.Product Specifications
Molecular Weight
166.17
Formula
C9H10O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4'-Hydroxy-3'-methoxyacetophenone
CAS Number
498-02-2
PubChem ID
2214
InChI Key
DFYRUELUNQRZTB-UHFFFAOYSA-N
SMILES
CC(C1=CC(OC)=C(O)C=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 100 | |
| Ethanol | 16.62 | 100 |
Preparing Stock Solutions
for Apocynin
The following data is based on the product molecular weight 166.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.20 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Impellizzeri Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 2011 PMID: 21147071
- Heumüller Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008 PMID: 18086956
- Stolk Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 1994 PMID: 8018341
Product Specific Notices for Apocynin
For research use only
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