LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
858 results for "LAG-3" in Products
858 results for "LAG-3" in Products
LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #BLR027F |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
![Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-BLR027F-Western-Blot-NBP2-76402-img0007.jpg "Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]")
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-reported |
| Chemical Name: | N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide |
| Purity: | ≥98% (HPLC) |
| Source: | CHO |
| Accession #: | P18627 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P18627 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-reported |
| Applications: | Ctrl, Simple Plex |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1058221 |
| Applications: | IHC, ICC |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1009614 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-reported |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
![Flow Cytometry: LAG-3 Antibody Pack [NBP3-11743]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-Pack-Flow-Cytometry-NBP3-11743-img0001.jpg "Flow Cytometry: LAG-3 Antibody Pack [NBP3-11743]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1009611 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #874512 |
| Applications: | Flow |
| Reactivity: | Cynomolgus Monkey |
| Details: | Rabbit IgG Monoclonal Clone #2561B |
| Applications: | Flow |