IL-18/IL-1F4: Antibodies
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
42 results for "IL-18/IL-1F4 Primary Antibodies" in Products
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IL-18/IL-1F4: Antibodies
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
42 results for "IL-18/IL-1F4 Primary Antibodies" in Products
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #125-2H |
Applications : | Block/Neutralize, ELISA Capture, Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #69604 |
Applications : | Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #1072H |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #74801 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Knockout Validated, Simple Western, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #74801 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #159-12B |
Applications : | ELISA Detection |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #74801 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #39-3F |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #925008 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #884801 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #74801 |
Applications : | CyTOF-ready, Flow Cytometry, Knockout Validated, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, ELISA, Immunocytochemistry/Immunofluorescence, Knockout Validated, Simple Western, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #93-10C |
Applications : | ELISA Detection |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #74801 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunocytochemistry/Immunofluorescence, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #914205 |
Applications : | Block/Neutralize |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #1072F |
Applications : | Block/Neutralize |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #159-12B |
Applications : | Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #74 |
Applications : | ELISA Capture, Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #93-10C |
Applications : | Block/Neutralize, Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #25-2G |
Applications : | Western Blot |