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9 results for "hedgehog-signaling-activators&view=expanded" in Products

C-terminal cholesterol, N-terminal fatty acid-modified

Reactivity:
Human
Source:
HEK293
Accession #:
Q15465
Applications:
Bioactivity
Enhanced Activity of Human Cell-expressed Sonic Hedgehog (Shh) Protein.
(3)

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Chemical Name:
N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Purity:
≥98%
Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

Hedgehog signaling activator; brain penetrant and orally bioavailable

Chemical Name:
3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide
Purity:
≥98%
Hedgehog signaling activator; brain penetrant and orally bioavailable

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Chemical Name:
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity:
≥98%
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Potent and high affinity Smo receptor agonist

Chemical Name:
3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity:
≥98%
Potent and high affinity Smo receptor agonist

High affinity and selective Smoothened (Smo) receptor antagonist

Chemical Name:
1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride
Purity:
≥98%
High affinity and selective Smoothened (Smo) receptor antagonist

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

Chemical Name:
2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Purity:
≥98%
BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

SAG synthesized to Ancillary Material Grade

Chemical Name:
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity:
≥98%
SAG synthesized to Ancillary Material Grade

Dihydrochloride salt of SAG; Smo receptor agonist

Chemical Name:
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride
Purity:
≥98%
Dihydrochloride salt of SAG; Smo receptor agonist
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