SAG New

Name: SAG
Brand: Tocris Bioscience
SKU: TB4366-RMU

Tocris Bioscience, part of Bio-Techne | Catalog # TB4366-RMU

COA / SDS

SAG synthesized to Ancillary Material Grade

Key Product Details

Description:	SAG synthesized to Ancillary Material Grade
Chemical Name:	3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity:	≥98%
Molecular Weight:	490.06

View Full Technical Details for SAG

Technical Data
Citations

Biological Activity for SAG

SAG (TB4366-RMU) is a potent Smoothened (Smo) receptor agonist (K_d = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC₅₀ ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons.

TB4366-RMU is an Ancillary Material Grade version of SAG (Cat. No. 4366). Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.

Find out more about our Ancillary Material Grade product range.

Technical Data for SAG

M. Wt	490.06
Formula	C₂₈H₂₈ClN₃OS
Storage	Store at -20°C(±5°C)
Purity	≥98%
CAS Number	912545-86-9
InChi Key	VFSUUTYAEQOIMW-UHFFFAOYSA-N
Smiles	ClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Product Documents for SAG

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.