Group III mGluR Antagonists Products

Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu₄, mGlu₆, mGlu₇ and mGlu₈. mGlu group III receptors are coupled to G_i/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in spatial learning and memory, and umami taste (mGlu₄), stimulation of photoreceptors (mGlu₆), long term depression (mGlu₇) and presynaptic inhibition in the perforant pathway (mGlu₈). The human genes for mGlu₄, mGlu₆, mGlu₇ and mGlu₈ receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.