XAP 044

Tocris Bioscience, part of Bio-Techne | Catalog # 5248

Potent and selective mGlu7 antagonist
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Key Product Details

Description

Potent and selective mGlu7 antagonist

View all Group III mGluR Antagonists »

Product Description

XAP 044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

Product Specifications

Molecular Weight

380.13

Formula

C15H9IO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one

CAS Number

196928-50-4

PubChem ID

5428913

InChI Key

XXZKJJYWINSUMJ-UHFFFAOYSA-N

SMILES

OC1=CC=C(C(C(OC3=CC=C(I)C=C3)=CO2)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.01 100
Ethanol 7.6 20

Preparing Stock Solutions for XAP 044

The following data is based on the product molecular weight 380.13

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.31 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for XAP 044

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XAP 044

For research use only

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