Fibroblast Activation Protein alpha/FAP Products
FAP (also known as seprase) is a transmembrane serine protease, and a soluble and enzymatically active form of FAP known as antiplasmin-cleaving enzyme (APCE) circulates in human plasma. FAP is expressed on reactive stromal fibroblasts in tumor tissue and wound healing and on synoviocytes in rheumatoid arthritis. It exhibits dipeptidyl peptidase activity with substrate specificity similar to DPPIV/CD26, which is specific for N-terminal Xaa-Pro sequences. FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin as well as several peptide hormones (e.g. Neuropeptide Y, Brain Natriuretic Peptide, Substance P, Peptide YY, and Incretins). The enzymatic activity is dependent on FAP association with DPPIV on the cell surface. The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion. In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity.
298 results for "Fibroblast Activation Protein alpha/FAP" in Products
298 results for "Fibroblast Activation Protein alpha/FAP" in Products
Fibroblast Activation Protein alpha/FAP Products
FAP (also known as seprase) is a transmembrane serine protease, and a soluble and enzymatically active form of FAP known as antiplasmin-cleaving enzyme (APCE) circulates in human plasma. FAP is expressed on reactive stromal fibroblasts in tumor tissue and wound healing and on synoviocytes in rheumatoid arthritis. It exhibits dipeptidyl peptidase activity with substrate specificity similar to DPPIV/CD26, which is specific for N-terminal Xaa-Pro sequences. FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin as well as several peptide hormones (e.g. Neuropeptide Y, Brain Natriuretic Peptide, Substance P, Peptide YY, and Incretins). The enzymatic activity is dependent on FAP association with DPPIV on the cell surface. The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion. In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity.
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [NBP3-13884]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-FAP-4853-Immunohistochemistry-Paraffin-NBP3-13884-img0002.jpg "Immunohistochemistry-Paraffin: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [NBP3-13884]")
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [NBP3-13883]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-FAP-4851-Immunohistochemistry-Paraffin-NBP3-13883-img0001.jpg "Immunohistochemistry-Paraffin: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [NBP3-13883]")
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) - Azide and BSA Free
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
![Protein Array: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) - Azide and BSA Free [NBP3-14220]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-FAP-4853-Azide-and-BSA-Free-Protein-Array-NBP3-14220-img0001.jpg "Protein Array: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) - Azide and BSA Free [NBP3-14220]")
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) - Azide and BSA Free
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
![Protein Array: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) - Azide and BSA Free [NBP3-14219]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-FAP-4851-Azide-and-BSA-Free-Protein-Array-NBP3-14219-img0001.jpg "Protein Array: Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) - Azide and BSA Free [NBP3-14219]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #JA56-11 |
| Applications: | IHC, WB, mIF |
| Reactivity: | Human |
| Details: | Rabbit Monoclonal Clone #BLR150J |
| Applications: | IHC, WB, ICC/IF, IP, mIF, +1 More |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Janelia Fluor® 669]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Janelia Fluor® 525]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Janelia Fluor® 525]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Janelia Fluor® 669]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Alexa Fluor™ Plus 680]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Alexa Fluor™ Plus 680]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Alexa Fluor™ Plus 488]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Alexa Fluor™ Plus 647]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Alexa Fluor™ Plus 647]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Alexa Fluor™ Plus 594]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Alexa Fluor™ Plus 488]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Alexa Fluor™ Plus 555]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4853) [Alexa Fluor™ Plus 594]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4853 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (FAP/4851) [Alexa Fluor™ Plus 555]
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #FAP/4851 |
| Applications: | IHC, MA |
Fibroblast Activation Protein alpha/FAP Antibody (1E5) - Azide and BSA Free
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #1E5 |
| Applications: | WB, ELISA, IP |
![Western Blot: Fibroblast Activation Protein alpha/FAP Antibody (1E5) [H00002191-M01]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-1E5-Western-Blot-H00002191-M01-img0005.jpg "Western Blot: Fibroblast Activation Protein alpha/FAP Antibody (1E5) [H00002191-M01]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, Flow |
![Western Blot: Fibroblast Activation Protein alpha/FAP Antibody [NB110-85534]](https://resources.bio-techne.com/images/products/Fibroblast-Activation-Protein-alpha-FAP-Antibody-Western-Blot-NB110-85534-img0006.jpg "Western Blot: Fibroblast Activation Protein alpha/FAP Antibody [NB110-85534]")
Human Fibroblast Activation Protein alpha/FAP Alexa Fluor® 750-conjugated Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #427819 |
| Applications: | Flow |
