5 results for "EAAT2/GLT1 Small Molecules and Peptides" in Products
EAAT2/GLT1: Small Molecules and Peptides
GLT1 is the major glial glutamate transporter that takes up more than 90% of glutamate from the synapse. GLT1b is a splice variant that contains 11 unique amino acids at the C-terminus that encode a PDZ binding domain. GLT1b was initially believed to be the neuronal isoform of GLT1, but it now appears that GLT1b is localized to astrocytes in the normal brain and to neurons in pathological conditions. In Lou Gehrig's Disease, GLT1a is decreased, while GLT1b is increased. There are also different expressions in hypoxic cells, which have not yet been fully elucidated.
Selective non-transportable inhibitor of EAATs
| Chemical Name: | DL-threo-β-Benzyloxyaspartic acid |
| Purity: | ≥98% (HPLC) |
EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
| Chemical Name: | (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid |
Potent, non-substrate EAAT2 inhibitor
| Chemical Name: | N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine |
| Purity: | ≥98% (HPLC) |
Potent and selective positive allosteric modulator of EAAT2
| Chemical Name: | 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one |
| Purity: | ≥98% (HPLC) |
Potent competitive inhibitor of L-glutamate uptake
| Chemical Name: | 7-Chloro-4-hydroxyquinoline-2-carboxylic acid |
| Purity: | ≥98% (HPLC) |
