4 results for "Dihydrofolate Reductase Inhibitors" in Products
Dihydrofolate Reductase Inhibitors Products
Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. Tetrahydrofolate is essential for de novo purine and thymidylate synthesis, hence DHFR has a critical role in cell growth and proliferation.
DHFR is the target for many cancer therapies including methotrexate because it is a key enzyme in cell replication. Basal and ...
Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART
| Chemical Name: | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid |
| Purity: | ≥98% (HPLC) |
Photoswitchable inhibitor of human dihydrofolate reductase
| Chemical Name: | N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid |
| Purity: | ≥95% (HPLC) |
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
| Chemical Name: | 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine |
| Purity: | ≥98% (HPLC) |
Cytotoxic agent
| Chemical Name: | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid |
| Purity: | ≥98% (HPLC) |
