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Carbonic Anhydrase XII/CA12: Small Molecules and Peptides

Carbonic anhydrases catalyze the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. Human members of the CAs are secreted (CA6), membrane-bound (CA4, 9 to 12 and 14), cytosolic (CA1 to 3, 7, 8 and 13) or mitochondrial (CA5A and 5B). Some CAs may serve as markers for tumors and hypoxia. A subset of CAs lack CA activity due to point mutations but retain esterase function.

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5 results for "Carbonic Anhydrase XII/CA12 Small Molecules and Peptides" in Products

5 results for "Carbonic Anhydrase XII/CA12 Small Molecules and Peptides" in Products

Carbonic Anhydrase XII/CA12: Small Molecules and Peptides

Carbonic anhydrases catalyze the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. Human members of the CAs are secreted (CA6), membrane-bound (CA4, 9 to 12 and 14), cytosolic (CA1 to 3, 7, 8 and 13) or mitochondrial (CA5A and 5B). Some CAs may serve as markers for tumors and hypoxia. A subset of CAs lack CA activity due to point mutations but retain esterase function.

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GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

Alternate Names: Topamax
Chemical Name: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Purity: ≥98% (HPLC)
GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors

Carbonic anhydrase inhibitor

Chemical Name: N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
Purity: ≥98% (HPLC)
Carbonic anhydrase inhibitor

High affinity and selective CA IX and CA XII inhibitor

Chemical Name: 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
Purity: ≥98% (HPLC)
High affinity and selective CA IX and CA XII inhibitor

Selective and potent COX-2 inhibitor

Chemical Name: 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Purity: ≥98% (HPLC)
Selective and potent COX-2 inhibitor

Standard selective D2-like antagonist

Chemical Name: (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Purity: ≥98% (HPLC)
Standard selective D2-like antagonist
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