Acetazolamide
Tocris Bioscience, part of Bio-Techne | Catalog # 6742
Carbonic anhydrase inhibitor
Key Product Details
Description
Carbonic anhydrase inhibitor
Product Description
Acetazolamide is a carbonic anhydrase inhibitor. Modulates epileptiform synchronization in rat brain slices. Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. Lowers intracranial pressure in healthy rats. Also potentiates the antitumor effects of the HDAC inhibitor MS 275 (Cat. No. 6208).Product Specifications
Molecular Weight
222.25
Formula
C4H6N4O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
CAS Number
59-66-5
PubChem ID
1986
InChI Key
BZKPWHYZMXOIDC-UHFFFAOYSA-N
SMILES
CC(NC1=NN=C(S(N)(=O)=O)S1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.23 | 100 |
Preparing Stock Solutions
for Acetazolamide
The following data is based on the product molecular weight 222.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.50 mL | 22.50 mL | 44.99 mL |
| 5 mM | 0.90 mL | 4.50 mL | 9.00 mL |
| 10 mM | 0.45 mL | 2.25 mL | 4.50 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hamidi Carbonic anhydrase inhibition by acetazol. reduces in vitro epileptiform synchronization. Neuropharmacology. 2015 PMID: 25937211
- Uldall Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats. Neurosci.Lett. 2017 PMID: 28219789
- Bertone Carbonic anhydrase inhibitor acetazol. shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction. Synapse. 2017 PMID: 28873252
- Bayat Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 PMID: 28235409
Product Specific Notices for Acetazolamide
For research use only
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