CAR/NR1I3: Small Molecules and Peptides
CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.
4 results for "CAR/NR1I3 Small Molecules and Peptides" in Products
4 results for "CAR/NR1I3 Small Molecules and Peptides" in Products
CAR/NR1I3: Small Molecules and Peptides
CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.
Potent liver X receptor (LXR) agonist; also CAR inverse agonist
| Chemical Name: | N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Selective CAR agonist
| Chemical Name: | 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime |
| Purity: | ≥98% (HPLC) |
Cytochrome P450 inhibitor; antifungal
| Alternate Names: | CLT |
| Chemical Name: | 1-(2-Chloro-α,α-diphenylbenzyl)imidazole |
| Purity: | ≥98% (HPLC) |
Human pregnane X receptor agonist; H1 antagonist
| Alternate Names: | Meclozine |
| Chemical Name: | 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride |
| Purity: | ≥99% (HPLC) |
