Calsyntenin-1: Proteins and Enzymes

Calsyntenin-1 (CST-1; also Alcadein-alpha) is a 140 - 150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of almost all neurons. Calsyntenin-1 is a calcium-binding protein that may regulate post-synaptic signaling and Amyloid Precursor Protein (APP) cleavage and gene activation. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes APP AICD gene activation.

Mature human CST-1 is a 953 amino acid ...