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126 results for "BMPR-IA/ALK-3" in Products

BMPR-IA/ALK-3 Products

Cellular responses to bone morphogenetic proteins (BMPs) are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. There are seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors that function in TGF-beta superfamily signal transduction. The type II receptors for TGF-beta and activin bind ligands with high affinity by themselves. In contrast, BMPR-II binding to BMP-2, BMP-4, and BMP-7 is facilitated by the presence of the type I receptor. The type I receptors are also known as activin receptor-like kinases or ALKs.

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Alternate Names: LDN 193189 2HCl
Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥98% (HPLC)
Application of LDN 193189 in motor neurons differentiated from iPSCs
(2)

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names: Compound C,BML-275
Chemical Name: 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity: ≥98% (HPLC)
Potent AMPK inhibitor; also BMP type I receptor inhibitor

LDN 193189 synthesized to cGMP guidelines

Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥99%
LDN 193189 synthesized to cGMP guidelines
Reactivity: Human
Details: Goat IgG Polyclonal
Applications: WB
Reactivity: Human
Details: Mouse IgG1 Monoclonal Clone #4B7B2
Applications: IHC, WB, ELISA, ICC/IF, Flow, +1 More
Western Blot: BMPR-IA/ALK-3 Antibody (4B7B2)BSA Free [NBP2-37421]
(7)
Source: NS0
Accession #: NP_004320
Applications: BA
Source: NS0
Accession #: NP_033888
Applications: BA
R&D Systems Recombinant Proteins and Enzymes

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Purity: ≥97% (HPLC)
Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water
Reactivity: Human
Details: Goat IgG Polyclonal
Reactivity: Human
Details: Goat IgG Polyclonal
Reactivity: Human
Details: Goat IgG Polyclonal
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