B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
418 results for "B7-H3" in Products
418 results for "B7-H3" in Products
B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, Flow, IHC, CyTOF-ready, +1 More |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_079516.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q5ZPR3 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | WB, Flow, CyTOF-ready, KO |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #3108D |
| Applications: | WB, Simple Western, IHC, mIF |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1090036 |
| Applications: | WB, Simple Western, IHC, mIF |
| Sensitivity: | 0.274 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q8VE98.1 |
| Applications: | BA |
| Assay Range: | 0.781 - 50 ng/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit Monoclonal Clone #BLR025F |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: B7-H3/CD276 Antibody (BLR025F) [NBP3-14669]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Western-Blot-NBP3-14669-img0002.jpg "Western Blot: B7-H3/CD276 Antibody (BLR025F) [NBP3-14669]")
| Source: | HEK293 |
| Accession #: | Q5ZPR3-1 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, KO |
![Knockout Validated: B7-H3/CD276 Antibody [NBP1-88966]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Knockout-Validated-NBP1-88966-img0016.jpg "Western Blot: B7-H3/CD276 Antibody [NBP1-88966]")
| Source: | CHO |
| Accession #: | NP_079516.1 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready, KO |
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2741D |
| Applications: | WB |