ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase: Proteins and Enzymes

ASAHL, or N-acylethanolamine-hydrolyzing Acid Amidase (NAAA), is a fatty acid amidase with maximal activity at acidic pH. ASAHL hydrolyzes a number of N-acyl ethanolamines, preferring N-palmitoylethanolamine. ASAHL is structurally similar to acid ceramidase. ASAHL is both a lysosomal and a secreted enzyme, and can be distinguished from anandamide amidohydrolase by its lack of inhibition by methyl arachidonyl fluorophosphonate.