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Angiotensin-Converting Enzyme Compounds: Small Molecules and Peptides

ACE (E.C 3.4.15.1) belongs to the protease family of enzymes and is a membrane-bound zinc metalloenzyme. The zinc ion within ACE directly participates in its protease activity and ACE can be inhibited by metal chelating agents. The ACE gene encodes two isoforms; a long, somatic isoform found in many tissues including vascular endothelial cells and kidney epithelial cells, and a short, germinal isoform expressed only in the testes and sperm.

Within the Renin Angiotensin System, ACE cleaves a ...

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Potent renin inhibitor; antihypertensive

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