11 results for "Amyloid beta Peptide Inhibitors" in Products
Amyloid beta Peptide Inhibitors Products
Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation; Aβ40 and Aβ42. Aβ40 is the most abundant form, but Aβ42 is more fibrillogenic, thus is associated with disease states.
Mutations in APP have been linked to early onset Alzheimer's ...
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% (HPLC) |
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
| Chemical Name: | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one |
| Purity: | ≥98% (HPLC) |
Potent and selective γ-secretase inhibitor
| Alternate Names: | L 458,γ-Secretase Inhibitor X |
| Chemical Name: | (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide |
| Purity: | ≥97% (HPLC) |
Inhibitor of JNK signaling
| Chemical Name: | (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester |
| Purity: | ≥97% (HPLC) |
β-secretase (BACE) inhibitor; inhibits amyloid assembly
| Alternate Names: | Epigallocatechin gallate |
| Chemical Name: | 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of PKCβII
| Chemical Name: | 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥98% (HPLC) |
Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
| Alternate Names: | AL-108,NAP (peptide),NAPVSIPQ |
| Purity: | ≥95% (HPLC) |
Inhibitor of Aβ42 fibril formation
| Chemical Name: | 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine |
| Purity: | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name: | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
