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9 results for "ALK/CD246 Small Molecules and Peptides" in Products

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ALK/CD246 Small Molecules and Peptides

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

GSK 1838705

Catalog #: 5111

Citations (3)

Product Documents

Images (1)

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

Chemical Name:

2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

Purity:

≥98%

ASP 3026

Catalog #: 5310

Citations (1)

Product Documents

Images (1)

Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor

Chemical Name:

N²-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Purity:

≥98%

TL 13-12

Catalog #: 6744

Citations (2)

Product Documents

Images (1)

Selective ALK Degrader (PROTAC®)

Chemical Name:

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

Purity:

≥98%

TL 13-112

Catalog #: 6745

Citations (3)

Product Documents

Images (1)

Selective ALK Degrader (PROTAC®)

Chemical Name:

N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide

Purity:

≥98%

TL 13-110

Catalog #: 6746

Product Documents

Images (1)

Negative control for TL 13-112 (Cat. No. 6745)

Chemical Name:

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide

Purity:

≥98%

TL 13-22

Catalog #: 6747

Product Documents

Images (1)

Negative control for TL 13-12 (Cat. No. 6744)

Chemical Name:

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide

Purity:

≥98%