TL 13-12
Tocris Bioscience, part of Bio-Techne | Catalog # 6744
Selective ALK Degrader (PROTAC®)
Product Description
TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h.Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
961.48
Formula
C45H53ClN10O10S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
CAS Number
2229037-04-9
PubChem ID
138108740
InChI Key
WXNUIPVZMJMPNM-UHFFFAOYSA-N
SMILES
COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 96.15 | 100 |
Preparing Stock Solutions
for TL 13-12
The following data is based on the product molecular weight 961.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.04 mL | 5.20 mL | 10.40 mL |
| 5 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 10 mM | 0.10 mL | 0.52 mL | 1.04 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Powell Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 2018 PMID: 29660984
Product Specific Notices for TL 13-12
For research use only
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