TL 13-22
Tocris Bioscience, part of Bio-Techne | Catalog # 6747
Negative control for TL 13-12 (Cat. No. 6744)
Key Product Details
Description
Negative control for TL 13-12 (Cat. No. 6744)
Product Description
TL 13-22 is a negative control for TL 13-12 (Cat. No. 6744). Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC50 = 0.54 nM)Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
947.50
Formula
C45H55ClN10O9S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
CAS Number
2229036-65-9
SMILES
COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCCNC5=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 94.75 | 100 |
Preparing Stock Solutions
for TL 13-22
The following data is based on the product molecular weight 947.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.06 mL | 5.28 mL | 10.55 mL |
| 5 mM | 0.21 mL | 1.06 mL | 2.11 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.06 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Powell Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 2018 PMID: 29660984
Product Specific Notices for TL 13-22
For research use only
Loading...
Loading...