SYM 2206

Name: SYM 2206
Brand: Tocris Bioscience
SKU: 0961

Tocris Bioscience, part of Bio-Techne | Catalog # 0961

COA / SDS

Non-competitive AMPA antagonist

Discontinued Product

0961 has been discontinued. View all AMPA Receptor Antagonists products.

Key Product Details

Description:	Non-competitive AMPA antagonist
Chemical Name:	(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine
Purity:	≥99% (HPLC)
Molecular Weight:	366.42

View Full Technical Details for SYM 2206

Technical Data
Citations

Biological Activity for SYM 2206

Novel, potent, non-competitive AMPA receptor antagonist (IC₅₀ = 2.8 μM ). Acts allosterically at the same regulatory site as GYKI 52466 (Cat. No. 1454) and GYKI 53655 (Cat. No. 2555) and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data for SYM 2206

M. Wt	366.42
Formula	C₂₀H₂₂N₄O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	173952-44-8
PubChem ID	5039877
InChi Key	OFUDZKKOKPGXOH-UHFFFAOYSA-N
Smiles	CCCNC(=O)N1N=C(C2=CC=C(N)C=C2)C2=C(C=C3OCOC3=C2)C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SYM 2206

References are publications that support the biological activity of the product.

Pelletier Substituted 1,2-dihydrophthalazines: potent, selective and non-competitive inhibitors of the AMPA receptor. J.Med.Chem. 1996 PMID: 8558499
Li Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature 1999 PMID: 9923678
Bleakman Kainate receptor agonists, antagonists and allosteric modulators. Curr.Pharm.Des. 2002 PMID: 11945137