GYKI 53655 hydrochloride

Name: GYKI 53655 hydrochloride
Brand: Tocris Bioscience
SKU: 2555

Tocris Bioscience, part of Bio-Techne | Catalog # 2555

Citations (32)

COA / SDS

Non-competitive non-NMDA iGluR antagonist

Key Product Details

Description:	Non-competitive non-NMDA iGluR antagonist
Chemical Name:	1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	388.85

View Full Technical Details for GYKI 53655 hydrochloride

Technical Data
Citations

Biological Activity for GYKI 53655 hydrochloride

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl₂- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC₅₀ = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC₅₀ = 32 μM) at high concentrations.

Technical Data for GYKI 53655 hydrochloride

M. Wt	388.85
Formula	C₁₉H₂₀N₄O₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	143692-48-2
PubChem ID	126757
InChi Key	ASLCSBBDVWPSQT-UHFFFAOYSA-N
Smiles	CC(N(C(NC)=O)N=C3C4=CC=C(N)C=C4)CC1=C3C=C(OCO2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GYKI 53655 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.88	100
	DMSO	38.88	100

Preparing Stock Solutions for GYKI 53655 hydrochloride

The following data is based on the product molecular weight 388.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.72 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for GYKI 53655 hydrochloride

References are publications that support the biological activity of the product.

Szabados Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res.Bull. 2001 PMID: 11489346
Perrais Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 2009 PMID: 18761361
Paternain Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 1995 PMID: 7826635