Rucaparib camsylate
Tocris Bioscience, part of Bio-Techne | Catalog # 6230
PARP inhibitor
Key Product Details
Description
PARP inhibitor
Alternative Names
CO-338
Product Description
Rucaparib camsylate is a PARP inhibitor. Chemosensitizes colorectal cancer cells to Temozolomide (Cat. No. 2706) and Topotecan (Cat. No. 4562) in vitro and in vivo.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
555.66
Formula
C19H18FN3O.C10H16O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
CAS Number
1859053-21-6
PubChem ID
53356947
InChI Key
INBJJAFXHQQSRW-FHIDHQGESA-N
SMILES
CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.57 | 100 |
Preparing Stock Solutions
for Rucaparib camsylate
The following data is based on the product molecular weight 555.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.80 mL | 9.00 mL | 18.00 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.60 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thomas Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 2007 PMID: 17363489
Product Specific Notices for Rucaparib camsylate
For research use only
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