Remacemide hydrochloride

Product Description

Remacemide hydrochloride is an non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC₅₀ = 8 - 68 mM). Remacemide hydrochloride is anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na⁺ channels (IC₅₀ = 161 mM). In an animal model of Huntington's disease, extends survival and delays disease; this effect is more pronounced when combined with Coenzyme Q10 (Cat. No. 3003)

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Solubility

Preparing Stock Solutions for Remacemide hydrochloride

The following data is based on the product molecular weight 304.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.28 mL	16.40 mL	32.81 mL
5 mM	0.66 mL	3.28 mL	6.56 mL
10 mM	0.33 mL	1.64 mL	3.28 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ferrante Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J.Neurosci. 2002 PMID: 11880489
• Santangeli Na⁺ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 2002 PMID: 11906711
• Subramaniam Block of the N-MthD.-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 1996 PMID: 8558426
• Palmer Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 1995 PMID: 7486610