(R)-(+)-Bay K 8644

Name: ( R )-(+)-Bay K 8644
Brand: Tocris Bioscience
SKU: 1545
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1545

(1)

Citations (3)

COA / SDS

CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor

Key Product Details

Description:	Ca_V1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
Chemical Name:	(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	356.3

View Full Technical Details for (R)-(+)-Bay K 8644

Technical Data
Citations / Reviews (1)

Biological Activity for (R)-(+)-Bay K 8644

(R)-(+)-Bay K 8644 is a L-type Ca²⁺-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Compound Libraries for (R)-(+)-Bay K 8644

(R)-(+)-Bay K 8644 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for (R)-(+)-Bay K 8644

M. Wt	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	98791-67-4
PubChem ID	6604881
InChi Key	ZFLWDHHVRRZMEI-CYBMUJFWSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@@H]1[C@]2=CC=CC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(+)-Bay K 8644

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	35.63	100
	DMSO	35.63	100

Preparing Stock Solutions for (R)-(+)-Bay K 8644

The following data is based on the product molecular weight 356.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (R)-(+)-Bay K 8644

References are publications that support the biological activity of the product.

Segovia Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation. Cancer Cell. 2019 PMID: 31085177
Shi Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 2008 PMID: 18983970
O'Neill and Bolger Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 1988 PMID: 2465070
Ravens and Schopper Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 1692975
Franckowiak The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 1985 PMID: 2412855